Website of D lab in Nagoya University

Welcome to the D lab's website!

Priciple of AFMDynamic actions of proteins, such as the conformational change and protein-protein interactions, are crucial to their biological functions. Usually, protein motions are unsynchronized and, therefore, difficult to monitor with ensemble-averaged experiments. In order to reveal the dynamic behavior of proteins, single-molecule approaches are indispensable. We are developing and implementing novel single-molecule techniques based on high-speed atomic force microscopy (HS-AFM). These techniques enable real-time visualization of molecules in action and allow to elucidate the function mechanisms of biological molecules with dynamic actions relevant to their unique tasks.

The D lab was established from the former J lab after Prof. Kouyama's retirement by Takayuki Uchihashi, who moved here from Kanazawa University on April 1st 2017. In April 2018 two fourth year students joined the other members (one PhD student from Kanazawa University, two researchers). Let's all work together to create a new and interesting lab!

By the way, it is often asked what the "D" of the "D lab" means: It is the first letter of "dynamics".


May 16, 2018 Our collaborative paper with Prof. Shibata (Kanazawa Univ.), Prof. Inoue (Univ. Tokyo) and Prof. Kandori (Nagoya Inst. Tech.) has been accepted by Scientific Reports.

May 9, 2018 Our collaborative paper with Prof. Watanabe (Konan Univ.), Prof. Uchiyama (Osaka Univ.), Prof. Murata (NIPS), Prof. Ando (Kanazawa Univ.) and Prof. Iino (IMS) has been accepted by Nature Communications.

May, 2018 A book entitled Nanoscale Inaming: Methods and Protocols in Methods in Molecular Biology (Chapter contribution) has been published.

April 5, 2018 Our collaborative paper with Prof. Fukuda (Saitama Univ.) and Prof. Umakoshi (Osaka Univ.) has been accepted by Colloids and Surfaces B: Biointerfaces.

April 4, 2018 Our collaborative paper with Prof. Yanai (Kyushu Univ.) has been accepted by ChemComm.

March 22, 2018  Mr. Kozai was awarded a President's Award for Students in Kanazawa University. Conglatulations! He has moved to Basel Univserity (Prof. Roderick Lim lab.)

March 15, 2018 Our collaborative paper with Prof. Furutani (IMS) has been accepted by Journal of Biogloical Chemistry.

March 3, 2018 Our collaborative paper with Prof. Minamino, Dr. Terahara, Prof. Namba (Osaka Univ.) and Prof. Kodera, Prof. Ando (Kanazawa Univ.) has been accepted by Science Advances.

February 20, 2018 Our collaborative paper with Prof. Hirota (NAIST) has been accepted by Chemistry - An Asian Journal.

January 24, 2018 Our collaborative paper with Dr. Marunoa and Prof. Uchiyama (Osaka Univ.) has been accepted by Journal of Pharmaceutical Sciences.


June 6, 7, 2018   JSPS Grant‐in‐Aid for Scientific Research on Innovative Areas"Studying the Function of Soft Moleculear Systems by the Concerted Use of Theory and Experiment, Achievements Report Meeting@Saitama

July 22-27, 2018 ICN+T 2018@Brno

August 20-24, 2018 4th International Conference on Scanning Probe Microscopy on Soft and Polymeric Materials (SPMonSPM) @Leuven

September 9-12   Annual meeting, the Physical Society of Japan@Kyoto

September 15-17   The 55th Annual Meeting of the Biophysical Society of Japan@Okayama