Dynamic actions of proteins, such as the conformational change and protein-protein interactions, are crucial to their biological functions. Usually, protein motions are unsynchronized and, therefore, difficult to monitor with ensemble-averaged experiments. In order to reveal the dynamic behavior of proteins, single-molecule approaches are indispensable. We are developing and implementing novel single-molecule techniques based on high-speed atomic force microscopy (HS-AFM). These techniques enable real-time visualization of molecules in action and allow to elucidate the function mechanisms of biological molecules with dynamic actions relevant to their unique tasks.

The D lab was established from the former J lab after Prof. Kouyama's retirement by Takayuki Uchihashi, who moved here from Kanazawa University on April 1^st 2017. In April 2018 two fourth year students joined the other members (one PhD student from Kanazawa University, two researchers). Let's all work together to create a new and interesting lab!

By the way, it is often asked what the "D" of the "D lab" means: It is the first letter of "dynamics".

April 10, 2019 　Our collaborative paper with Prof. Hirota, Prof. Kamikubo (NAIST) and Prof. Shimizu (KEK) has been accepted by ACS Synthetic Biology.

April 8, 2019 　Our collaborative paper with Prof. Suzuki (Shinshu Univ.) has been accepted by Angewandte Chemie International Edition.

March, 28, 2019 New students have joined! (member).

March, 26, 2019 Christian Ganser(JSPS Reserach Fellow)was awarded the Best Presentation Award at the Chubu Branch Meeting of the Biophysical Society Japan (photo). Congratulations!

March, 14, 2019　Our collaborative paper with Dr. Umakoshi (Osaka Univ.), Prof. Iino (IMS) and Prof. Ando (Kanazawa Univ.) has been accepted by BA - General Subjects.

Feubruary 11, 2019　Our collaborative paper with Prof. Kikkawa and Dr. Owa (Univ. Tokyo) has been accepted by Nature Communications.

January 19, 2019　Our collaborative paper with Prof. Murata (Chiba Univ.) has been accepted by Scinence Advances.

December 1, 2018　Our collaborative paper with Prof. Oohora and Prof. Hayashi (Osaka Univ.) has been accepted by Chemical Communications.

November 20, 2018 Christian's paper has been accepted by Nanoscale. Congratulations, Christian!

September 28, 2018 Our collaborative paper with Dr. Sugiyasu, Dr. Fukui and Dr. Takeuchi (NIMS）has been accepted by Angewandte Chemie International Edition.

August 24, 2018　Our collaborative paper with Mr.Matsui and Prof. Suzuki (Shinshu Univ.) has been accepted by ACS Omega.

August 16, 2018　Dr. Hiroki Watanabe (Visiting Researcher) has move to Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences as a specially appointed assistant professor.

August 1, 2018　Our collaborative paper with Prof. Oohora and Prof. Hayashi (Osaka Univ.) has been accepted by Journal of American Chemical Society.

July 30, 2018　Our collaborative paper with Dr. Haruyama and Prof. Tsukazaki (NAIST) has been accepted by Structure.

July 10, 2018　Our collaborative paper with Prof. Johnson and Dr. Mori (Vanderbilt Univ.) has been accepted by Nature Communications.

May 16, 2018　Our collaborative paper with Prof. Shibata (Kanazawa Univ.), Prof. Inoue (Univ. Tokyo) and Prof. Kandori (Nagoya Inst. Tech.) has been accepted by Scientific Reports.

May 9, 2018　Our collaborative paper with Prof. Watanabe (Konan Univ.), Prof. Uchiyama (Osaka Univ.), Prof. Murata (NIPS), Prof. Ando (Kanazawa Univ.) and Prof. Iino (IMS) has been accepted by Nature Communications.

May, 2018　A book entitled Nanoscale Inaming: Methods and Protocols in Methods in Molecular Biology (Chapter contribution) has been published.

June 25, 2019　 Joint Annual Meeting of 71st JSCB & 19th PSSJ＠Kobe

July 4-8, 2019　 2019 IEEE International Conference on Manipulation, Manu­facturing and Measurement on the Nanoscale (3M-Nano)＠Zhenjiang, China